Peyronie's Disease

Peyronie's disease is pathological condition affecting the penis. Although it is not life-threatening, it can significantly impair the quality of life and especially its sexual aspects. It used to be considered a rare disease, but is now we know that it may affect up to 5% of men over 50 years of age.


The main reason is excessive production of solid scarred connective tissue in the soft tissues of the penis. The underlying mechanism is usually not clear, but the disease affects more frequently the males with reported penis injuries (such as injuries during sexual activity). The process of development of Peyronie's disease can be therefore considered as a certain failure of wound healing. In addition, it is assumed that there is a genetic condition increasing the risk of the disease. Some doctors even think about autoimmune cause of the disease. The Peyronie's disease is non-malignant and it is also not contagious.

Peyronie's disease


Penis deformed by an advanced form of Peyronie's disease



The disease manifests with pain and deformation of the penis. In advanced forms of the disease, the penis significantly bends causing pain during erection and erectile dysfunction. Untreated severe forms of the Peyronie's disease make sexual intercourse practically impossible.


The patient should be examined by a urologist. The condition is usually clearly visible and no other examination methods are needed.


Less severe forms are often just regularly monitored and the patient is administered various supportive medicine and supplements including (vitamin E, interferons, pentoxyfylline, coenzyme Q10 and others). However, the pharmacotherapy has not a very convincing outcome. More advanced forms of the disease are treated surgically. The surgical intervention aims to return the penis back to its normal shape. However, even the successful surgeries may decrease the sensitivity of the penis without improving the erectile dysfunction.


Jiri Stefanek, MD  Author of texts: Jiri Stefanek, MD
 Sources: basic text sources