Ewing's sarcoma is a rare malignant tumor occurring mostly in children and adolescents. Its prognosis is not the best and despite its less frequency it is good to know some basic information.
There is certainly a genetic precondition of development of the disease, because some certain chromosomal abnormalities have been found in the tumor cells. The tumor is traditionally classed into the group of bone cancers, but the histological classification of tumor cells is somewhat more complicated.
The tumor develops from blood marrow cells and usually affects long bones of the body, pelvis and ribs. The most common symptom is pain in the affected bone and formation of pathological fractures. When the bone is close to body surface, the mass of the tumor may be palpable. Advanced forms of the disease manifest by overall malignant disease symptoms by metastatic spread.
The therapy depends on the tumor size and stage. Ewing's sarcoma is highly sensitive to the chemotherapy and radiotherapy. Where possible, the best solution is a local surgical intervention with removal of the tumor and adjacent bones. When the tumor affects a limb, the amputation is often performed. Widespread forms of the disease have a poor prognosis despite maximal therapy.