Enlarged Prostate Medications

Drugs for enlarged prostate are very frequently used medications in elderly men, in whom the prostate problems are quite common. The mechanisms of action of these drugs are different. Their aim is, however, similar - to reduce the prostatic volume and to allow free flow of urine.


Drugs for enlarged prostate include for example the so-called alpha-blockers. The alpha-blockers act on smooth muscles of prostatic urethra and relax it. This enlarges the lumen of the tube and improves urination. Another group of drugs are inhibitors of 5-alpha-reductase. They act on the metabolism of male sex hormone testosterone, which is responsible for prostate growth and cause reduction of prostatic volume. Favorite drugs are even some phytopharmaceuticals, i.e. medicines made ​​from extracts of certain plants with anti-inflammatory and anti-swelling effects.


The drugs are administered to men with symptoms of enlarged prostate. The main objective is to reduce its volume and prevent disorders of urine outflow. Some alpha-blockers decrease high blood pressure and can be used as antihypertensives.

Used substances

The most commonly used substances include alfuzosin (alpha-blocker), doxazosin (alpha-blocker), tamsulosin (alpha-blocker), terazosin (alpha-blocker), finasteride (inhibitor of 5-alpha reductase), dutasteride (inhibitor of 5-alpha reductase) and fruit extracts from dwarf palm (phytopharmaceutical).

Adverse effects

Adverse effects are usually not serious. Alpha-blockers may cause erection disorders, headaches, dizziness, indigestion, skin rash, and palpitations. Inhibitors of 5-alpha-reductase also cause sexual disorders, including disruption of ejaculation, decreased libido, impotence, sense of breast tension and gynecomastia. Relatively rare are skin reactions with rash and skin itching. Phytopharmaceuticals have only minor negative effects on digestion.


Jiri Stefanek, MD  Author of texts: Jiri Stefanek, MD
 Contact: jiri.stefanek@seznam.cz
 Sources: basic text sources